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doi: 10.1111/j.1365-2796.2009.02079.x 303 JammesYSteinbergJGDelliauxS

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And across all comparisons, most GI events are mild to moderate in severity, transient, and concentrated during dose escalation periods

Clinical trials evaluating semaglutide have not identified bone loss as a significant adverse effect, though it should be noted that bone mineral density (BMD) was not specifically assessed in most studies