Injection sites commonly include the abdomen, thigh, or upper arm
Medications Statins (first-line) Ezetimibe, PCSK9 inhibitors Fibrates (for triglycerides) LDL = main target for cardiovascular risk reduction HDL protective, total cholesterol alone is less informative Familial hypercholesterolemia early CAD, tendon xanthomas Cholesterol is a lipid essential for cell membranes, steroid hormones, and bile acids, with LDL increasing cardiovascular risk and HDL being protective To view or add a comment, sign in Insulin: The Master Regulator of Whole-Body Metabolism Insulin is often simplified as a blood glucose In reality, insulin functions as a central metabolic signal that coordinates energy balance, nutrient partitioning, vascular health, immune activity, and inter-organ communication
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Necroinflammation The inflammatory responses that emerge when cells die via inflammatory cell death modalities such as necroptosis or pyroptosis which trigger the uncontrolled release of cellular contents (so-called danger signals) into surrounding tissues leading to activation of immune cells that drive inflammation
Most therapies are weekly, some bi-weekly and maintenance therapies are often monthly
NICE guideline NG28 recommends a stepwise approach to type 2 diabetes management, with treatment intensification based on glycaemic control and individual patient factors
