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Most patients experience gastrointestinal symptoms, including diarrhea, during the initial weeks of treatment or when doses are increased

Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts

doi: 10.1126/scisignal.2005375 143 AhmadADempseySKDanevaZAzamMLiNLiPLet al

Most patients begin at a lower starting dose and move up gradually at intervals set by your prescriber, commonly about every 4 weeks, allowing side effects to stabilize between increases

For some individuals, this can create a balancing act that requires dose adjustments

The label states 2 mg per dose, meaning two vials are used per injection