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10.1007/s12035-015-9602-7 241 StamelouM.TuschlK.ChongW

10.1177/03635465990270031701 42 LaiF.WangJ.TangH.HuangP.LiuJ.HeG.et al (2022)

DOI:10.5772/INTECHOPEN.71547 Pedrajas, J

The unsupervised clustering of 4453 fibroblasts was used to analyze the senescent cells in keloid and normal skin fibroblast based on senescence-associated marker genes, CDKN2A, TP53, CDKN1A (also known as p21 ) , LMNB1, H2AFX, TP53BP1, SFRP4, CCND1 and GLB1 according as previously reference 20,21

Long-term studies have shown no receptor desensitization with continued use, meaning it remains effective over months and years without requiring dose escalation

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