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A 2025 Stanford Medicine study identifying a naturally occurring peptide that suppressed appetite and reduced body weight without the nausea and muscle loss associated with semaglutide confirmed what many clinicians had already observed: the GLP-1 mechanism is powerful, but it carries side effects tied directly to how it works

First, setting realistic expectations at the start of therapy is essential

Journal reference: Tejeji I., Zeier T., Smith J

However, the intended recipient of the medication is different

doi: 10.4239/wjd.v12.i7.1042 2 GaberySSalinasCGPaulsenSJAhnfelt-RnneJAlanentaloTBaqueroAFet al

Some studies suggest that unsaturated fats may promote greater GLP-1 secretion than saturated fats, though more research is needed