2) (Bouckenooghe et al
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Patients should be advised about the urine discoloration (to avoid alarm) and counseled to report any persistent side effects
Neurological manifestations are among the most concerning signs: Paraesthesia (pins and needles) in hands and feet Numbness or altered sensation in extremities Difficulty with balance or coordination Memory problems or difficulty concentrating Mood changes, including depression or irritability Visual disturbances in rare cases These symptoms may be particularly difficult to distinguish from diabetic neuropathy, making objective assessment through blood testing essential rather than relying solely on clinical presentation
Interestingly, the number of altered metabolites were much lower between LC and HC groups, showing 61 and 76 decreased and increased, respectively ( Figure 2G )
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