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Sitagliptin Based on 31 publication(s) in Google Scholar Sitagliptin (MK-0431) is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM

It also bumps up against the mechanism of action of GLP-1s, which are approved by the FDA for long-term weight management because their discontinuation can lead to weight regain

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Its not caused by the medication itself, but by the rapid fat loss throughout the bodyincluding facial fat compartmentscombined with decreased collagen and elastin production during weight loss