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IGF-1 activates cells and increases the number of androgen receptors, and at 30 years of age, then 300 mg of testosterone propionate will act the same as at 20 years of age

Another investigation found that hepatoma-derived growth factor (HDGF), secreted from activated Mller cells, enhances microglial polarization toward a pro-inflammatory M1 phenotype via Dectin-1 signaling, worsening cytokine storms and BRB disruption in early NPDR (53, 54)