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Such mutation induces a hyperactivity of the LRRK2 kinase, known to be highly neurotoxic

(1) Both these findings on chronic and acute action of AOD 9604 suggested that while enhanced beta(3)-AR expression may have played a role in the chronic action of the compound, beta(3)-AR might not be the sole arbiter in this reaction

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Avoid in patients with peptic ulcers or renal impairment