F., Nauck, M
While current evidence does not establish a direct causal relationship between tirzepatide and gastrointestinal bleeding, tirzepatide's known gastrointestinal effectsincluding nausea, diarrhea, vomiting, and constipationmay indirectly contribute to conditions that cause rectal bleeding
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Evening injectors sometimes experience nausea while sleeping, which disrupts rest without providing any appetite-suppression benefit since they are not eating anyway
That effect, he says, may be tied to changes in the brains reward system