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The initiation phase involves the generation of ROS, including free radicals like hydroxyl radicals (OH), superoxide anions (O 2 ), and non-radical oxidants like hydrogen peroxide (H 2 O 2 ) [48, 49]

Zoological Journal of the Linnean Society

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doi:10.1136/bmj-2021-066452

And theres a higher chance of recurrence with antibiotics-only treatment: In a study published in 2015 , among patients with uncomplicated appendicitis treated only with antibiotics, 27 percent required surgical intervention within a year