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Weight loss effects vary by population, with clinical trials showing up to 21-22% mean weight loss in obesity trials (non-diabetes patients) and lower percentages in type 2 diabetes patients, depending on dose

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However, in AD, tau becomes hyperphosphorylated to detach from microtubules and form toxic neurofibrillary tangles that impair cellular transport and accelerate neuronal death (Ye et al., 2025)

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