Insulin lowers blood sugar, while glucagon raises it
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Phentermine and Topiramate - Clinical Pharmacology 12.1 Phentermine and Topiramate Mechanism of Action Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine (d- and d/l-amphetamine)
Under stress conditions, the GSTM1-1ASK1 complex dissociates, causing the oligomerization of GSTM1-1 and the activation of ASK1, which subsequently activates JNK and P38 pathways, leading to apoptosis [66]
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This multi-receptor mechanism combines GLP-1R- and GIPR-driven appetite suppression with GCGR-mediated increases in energy expenditure