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However, evidence also suggests that metformin may have cognitive benefits in certain contexts, as it has been shown to enhance attention, inhibitory control, and associative learning in younger non-transgenic C57BL/6 mice (16 months) 92

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High potassium levels can be life-threatening, and respond to increased urine production and renal replacement therapy (see below)

Extend the current dose level by 4 additional weeks if nausea at any step is grade 2 or higher (interfering with daily activity)

Here are some general guidelines I discuss with my patients: Dr

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