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Dosage recommendations reflect clinical practice patterns and preclinical dose extrapolation, not FDA-approved labeling

Intravenous and intramuscular administration bypasses the digestive system, which metabolizes the substance and sends only a portion to cells

For instance, a number of variants in the GCL gene have been associated with cystic fibrosis [39], and COPD [40]

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10.1002/anie.201601967 99 UranoY.IwagakiA.TakeishiA.UchiyamaN.NoguchiN