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Summary Keywords body composition, GLP-1 receptor agonists, gutbrain axis, lean mass preservation, postbiotics, resistance training, short-chain fatty acids, weight regain Citation Cengiz Kaynakc E (2026) Potential role of postbiotics in supporting lean mass preservation and weight-loss sustainability during GLP-1based anti-obesity therapy

Its a DUAL-ACTION GLP-1/GIP that is approved by the FDA for people with obesity BMI 30, or overweight BMI 27 plus a weight-related condition, along with diet and exercise changes

Compliance with Ethics Guidelines The PIONEER trial protocols were approved by institutional review boards or independent ethics committees at each participating trial site, and were undertaken in accordance with ICH Good Clinical Practice guidelines and the Declaration of Helsinki

Johnson CY et al

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