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Although no significant change was observed in the bone formation marker P1NP, the semaglutide group showed a significant increase in the bone resorption marker CTX and a reduction in areal BMD at both the lumbar spine and total hip

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Three overlapping trends that may signal trouble for women who are losing both fat and muscle mass at a vulnerable time in their lives, according to Kohrt: Women in menopause lose bone at an accelerated rate due to declining levels of estrogen, which supports bone health

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GK rats, Goto-Kakizaki rats