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A systematic review of 86 studies in Sleep Medicine Reviews found strong evidence that the perimenopausal decline in estrogen and progesterone directly drives early morning awakenings, increased nighttime wakefulness, and reduced total sleep time

Int J Curr Microbiol Appl Sci 4(5):10331042 Ducey TF, Ippolito JA, Cantrell KB, Novak JM, Lentz RD (2013) Addition of activated switchgrass biochar to an aridic subsoil increases microbial nitrogen cycling gene abundances

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-HB must be transported across both the plasma membrane and the inner mitochondrial membrane

First isolated in the 1970s from the cerebral venous blood of sleeping rabbits, DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide whose biology has fascinated and puzzled neuroscientists for half a century