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However, most biological compounds tested for their effects on gene expression using computer-based tools often lack supporting biological data

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Although a number of studies identifying a key role for metformin in the gut were undertaken many years ago, more recent studies have focused on metformin action in the liver, where it undoubtedly exerts a glucose-lowering effect

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Because effect sizes vary by indication, dosing, individual factors, and adherence, a thoughtful provider frames frequency as something to reassess rather than fix permanently