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Nat Commun 9(1):1286 Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M (2013) Metformin improves healthspan and lifespan in mice

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Different mechanisms, different side-effect profiles