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2 The assessment did not provide a separate standardised definition or evaluation for a BPC-157 arginate material

1 and are summarized in detail below

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Abnormal ROS signalling in OA synovial fibroblasts induced by cytokines, thrombin or stress is related to the increased activity of nuclear factor erythroid 2 p45-related Factor 2 (NFE2L2, also known as NRF2) (Bernard et al., 2017)

At physiological concentrations, ROS is important to cellular division, but excessive ROS leads to stressed damages to protein, DNA and lipid (Mani et al., 2020)

doi: 10.1038/1841848a0