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for example, SCC from glabrous (smooth, hairless) sun-exposed skin has a lower metastatic rate than SCC arising from the vermillion border of the lip or from scars.[3] Additionally, in the epidermal compartment, melanocytes distribute singly along the basement membrane and can undergo malignant transformation into melanoma

This gradual approach helps to avoid the stark contrast that can sometimes result from more aggressive whitening treatments

However, there is currently a significant gap in research on the microbiota-associated metabolism of GRP/SFN

Kobayashi, Y

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PMID: 31210841