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The effects of these drugs on body weight regulation may be manifest through targets beyond appetite

Amlodipine exhibited the strongest binding affinity to the BSA molecule, with a score of 5.5 kcal/mol

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Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24

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