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Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

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Moreover, it is thought to reduce the risk of kidney disease progression, cardiovascular death, and hospitalization for heart failure

By helping individuals eat fewer calories, the body may begin using stored fat for energy over time

Patients who want help with cravings, loss of control eating, or persistent hunger often find this mechanism less helpful than they expected, because orlistat does not directly reduce appetite or alter food reward