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There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]

If so, why

While GLP-1s are powerful, they are not a "fix" for an untreated thyroid condition

Cyanocobalamin is more stable, less expensive, and the standard UK recommendation for oral treatment of dietary B12 deficiency at 50-150 micrograms daily

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Most HRT side effects are mild and settle within the first few months, and the serious risks are rarer than the headlines suggest