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in CPT: Pharmacometrics and Systems Pharmacology confirmed that the 5-day half-life, combined with weekly dosing, produces the accumulation ratio and steady-state concentrations that support these outcomes

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2009 Apr;9(4):327-38

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de Smedt H, Eggermont JA, Wuytack F, Parys JB, Van den Bosch L, Missiaen L et al (1991) Isoform switching of the sarco(endo)plasmic reticulum Ca2 + pump during differentiation of BC3H1 myoblasts

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