If you want a less concentrated solution for easier dosing, you could add 2mL of water for a final concentration of 25mg/mL
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
Future studies measuring follicular fluid B12, homocysteine, and methylation markers are needed to validate these pathways
What has your experience been
Vitamin B12 deficiency occurs when your body does not get enough Vitamin B12 from the food that you consume, which it requires to work properly
Increased Energy and Performance: Many individuals using 5 amino 1mq report improvements in daily energy levels and physical performance
