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The main symptoms are numbness and tingling of the thumb, index finger, middle finger, and the thumb side of the ring finger, as well as pain in the hand and fingers

Common adverse effects include nausea, vomiting, diarrhoea, and constipation , particularly during dose escalation

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Some studies suggest that unbound GHK (without copper) may be just as effective in skin regeneration, sparking debates about whether copper binding is necessary

A 0.5-inch drill was used to bore a hole through the bottom of desired wells