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In a research context, the main limitations are the gap between animal and human data, stability sensitivity requiring proper storage, and the risk of compromised results if purity is not independently verified

Chromone and flavonoid alkaloids: occurrence and bioactivity

Some individuals are more GI-sensitive than others

However, eryptosis has been suggested to have certain advantages for hemocompatibility testing and can be used to supplement data of hemolysis assays [450]

This effect is also favored from the production of IL-2, that sustain Tregs expansion, in unaffected by A1AT (58)

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