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Clinical trials of GLP-1 medications, including the STEP program for semaglutide and SURMOUNT trials for tirzepatide, have documented improvements in physical function scores and quality of life measures

They also function to disrupt the positive feedback mechanism involving local prostaglandin production that is responsible for further increasing estrogen levels in ectopic endometrial cells (34)

CCK receptors on VAN CCK neurons are coexpressed with leptin receptors (61)

However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited

Most programs, including physician-led ones in Georgia, follow guidelines from the Obesity Medicine Association and the FDAs approval criteria

Ours was among the first, maybe the first study, that was published on GLP-1s in breast cancer, but it was a very small cohort that came out of Memorial Sloan Kettering