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CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life

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On the other hand, several studies proved that perinatal choline supplementation in Ts65Dn mice has beneficial effects on Ts65Dn offspring, including improvements in attention, emotion regulation, spatial memory, and the protection of cholinergic neurons in the medial septal nucleus (MSN) [107, 108, 111]

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