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Mitochondrial Glutathione Reductase Mitochondrial glutathione reductase, while representing a smaller fraction (approximately 10-15%) of total cellular GR activity, fulfills a critical protective function within the mitochondriathe primary site of reactive oxygen species generation in cells

If the kidneys are already under strain (which is common with age, diabetes, or high blood pressure), this direct load can be too much to handle

Y.MouZ.et al (2014)

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Patient-specific prescriptions in narrow circumstances remain a fact-specific legal question that depends on state board interpretation, the pharmacists judgment, and the prescribers clinical rationale not a green light from the FDA