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People are often interested in why, when it costs a couple pennies to make this drug, manufacturers charge so much money for it, says Joseph F

Constipation affects a significant percentage of patients

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First, exendin-4 activated GLP-1R/cAMP/PKA pathway and attenuated endoplasmic reticulum stress in order to inhibit bone marrow-derived MSC apoptosis mediated by oxygen, glucose, and serum deprivation (57)

[1] This represents a selective adaptation rather than global tolerance to the medication