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The opioid, cocaine, and speedball epidemics created another unexpected observation

In addition to impaired oxygen consumption in patient brains, other experiments have observed decreased glucose metabolism, adding more proof of bioenergetic dysfunction and mitochondrial dysfunction in the disease [43]

Protein adduct formation occurs more quickly following administration of AMAP to mice than following administration of acetaminophen, and liver protein adducts derived from AMAP are less long lived than protein adducts derived from acetaminophen (Rashed et al

The present study aimed to investigate whether that potential extends to cocaine use