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KESA recapitulated the significant downregulation of multiple kinases involved in various pathways in GPR146 knockdown cells, including cAMP-PKA signaling (PRKAA2, PRKACG, PRKACA, PRKAC), mTOR signaling (RPS6KB1, RPS6KA1), PI3K-AKT signaling (AKT1, AKT2, PRKDC), MAPK signaling (RAF1, MAPK8) and PKC signaling (PRKCG, PRKCA) (Fig

Therefore, we identified GSTM2 as an important negative regulator in progression of hepatic steatosis via both its detoxification/antioxidant and inhibition of ASK1-p38/JNK signalling

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