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Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot

Oxidative stress is crucial in atherogenesis (144151), suggesting that a specific antioxidant/prooxidant imbalance, characterized by a weak GSH-related enzymatic antioxidant shield present in human atherosclerotic lesions, may be involved in atherogenic processes in humans (152)

The channel is also activated by phorbol esters, low pH, citrate, arachidonic acid, exogenous chemicals (bisandrographolide A) and heat (24C ) (Gler et al., 2002

As such, it is possible that redox-associated extrahepatic mechanisms may contribute to the activation of the hepatic AMPK pathway

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Geng, R