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Tirzepatide is the first in a class of drugs called dual GLP-1/GIP receptor agonists that activate the receptor for another gut hormone, glucose-dependent insulinotropic polypeptide (GIP), in addition to the GLP-1 receptor

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After activation by full agonists such as GLP-1, GLP-1R couples with Gs, activates adenylate cyclase (AC), and causes the accumulation of cAMP

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doi:10.2147/COPD.S350133 Dicker D, Sagy YW, et al