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These results correlate with previously published data, which have shown that stimulation of bFLS by bTNF- increases the expression of HIF-1, GLUT1 and PDK1, which favors a glycolytic metabolic phenotype-like 29

30 Three of the four RCTs of B12 alone used oral B12 (1000 g per day) and one used i.m

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Billon 2024 (Journal of Pharmacology and Experimental Therapeutics) Preclinical in vivo, 12-28 days, DIO C57BL/6J and ob/ob mice (n = 7-8 per group)