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Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

Five smaller meals spread throughout the day prevent the stomach from ever becoming uncomfortably full

When lymphatic fluid backs up in your legs, it causes swelling that can range from mild to severe

The evidence is strongest for semaglutide and tirzepatide