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The how much question has two parts: concentration and frequency

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Some patients may also experience fatigue or mild stomach discomfort, especially during the first few weeks of treatment

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Circadian variation in the efficacy of tissue-type plasminogen activator

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