( 10.1016/S0140-6736(1460976-4) [DOI] [PubMed] [Google Scholar] 104.Ahmann AJ, Capehorn M, Charpentier G, Dotta F, Henkel E, Lingvay I, Holst AG, Annett MP, Aroda VR
This is why compounded alternatives have become so popular for cash-pay patients
The former are nitrile-containing inhibitors that act on the DPP4 substrate involving production of a reversible covalent enzymeinhibitor complex, which gradually and slowly dissociates from the substrate leading to a lasting inhibitory activity, even after the drug has been inactivated
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