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GSH, GSSG, and the GSH:GSSG ratio were measured by enzymatic assay in bronchoalveolar lavage (BAL) fluid and in fresh epithelial cells from healthy controls (HCs), mild/moderate (M/M), and severe asthma (SA) patients

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Overall, redox homeostasis was disrupted, as reflected by increased intensities of metabolites that induce reactive oxygen species, and decreased metabolites that moderate oxidative stress (Fig

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Seattle, WA: University of Washington, Seattle