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The OGDHc is particularly sensitive to lipoyl glutarylation, with ABHD11 inhibition impairing normal OGDHc catalysis and perturbing 2-oxoglutarate (2-OG) metabolism

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These include stacking of W81 against YPEL5 R41, whose substitution impairs ZZ1 activity both in vitro and in cellulo (Fig

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Figure 1 4.1 Macrophage fatty acid metabolic disorders potentiate MSU crystal-induced inflammation Numerous studies have shown that the inflammatory factor interleukin-1 beta (IL-1) is essential for MSU crystal-driven inflammation and is released, in place of infiltrating neutrophils or monocytes, from the resident macrophages in the initial stage of GA (38, 39)