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While not commonly reported with Pendulum specifically, people sensitive to gut-brain interactions may notice temporary mood fluctuations during the adjustment period

A characteristic feature is the loss of interstitial cells of Cajal, likely secondary to immunological changes, such as a shift from protective M2 to M1 macrophages and impaired regulation of haem oxygenase-1, leading to oxidative stress

This documentation serves multiple purposes: regulatory review, institutional oversight and scientific integrity verification

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It's crucial to emphasize that these observations are largely based on preclinical research, making generalizations to human physiology premature