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Subsequent randomised data from Xu et al

These issues must be investigated and resolved systematically, as such a discrepancy is not a normal occurrence.

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Specifically, GSH-triggered activation of OC(O)O-based 1,2-dithiolane prodrugs is primarily driven by disulfide bond cleavage and subsequent intramolecular cyclization

[2] [3] Additionally, because the compound promotes blood vessel formation (angiogenesis), there are theoretical concerns about potential cancer promotion that require further investigation