It is important to note that hepatic IR reduced the extent of hepatic glycogen metabolism during fasting and feeding [38]
What gets ignored is what already happens after these compounds leave the clinic, or bypass it entirely
NNMT inhibition reduces one methylation pathway, but it doesn't directly deplete systemic methyl donorsit redirects nicotinamide away from methylation toward NAD+ salvage
Clin Transl Med 11:e382 Yang W, Wang Y, Zhang C, Huang Y, Yu J, Shi L, Zhang P, Yin Y, Li R, Tao K (2022) Maresin1 protect against ferroptosis-induced liver injury through ros inhibition and nrf2/ho-1/gpx4 activation
Note that the patients are not consulted they are just dictated to
Original draft preparation: S.B., K.R., K.H.-B., E.S., J.B