[PMID: 32375142] [7]Mar M, et al
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Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals
In the IMPACT trial, pemvidutide achieved mean weight losses of 4.8% and 5.8% with 1.2 and 1.8 mg doses respectively at 24 weeks, compared to 0.5% with placebo, with weight loss curves showing no evidence of plateauing, suggesting continued benefit with longer treatment [49-51]
J Appl Physiol 110:774780 Clinicaltrials.gov