Emerging data have implicated metabolic mis-regulation as a fundamental pathogenic pathway in all phases of RA
When the eyes detect light, signals are sent through a special pathway to the brains master body clock, called the suprachiasmatic nucleus (SCN)
Reported mechanisms should be read as hypotheses from laboratory and animal data
Influenza, norovirus, and other viral infections can affect multiple family members over a short period of timeoften leading to cumulative fatigue, dehydration, and prolonged recovery
In recent works, the study demonstrated that GCH1/ BH4 pathic enzyme dihydrofolate reductase (DHFR) could inhibit ferroptosis by generating BH4, so decrease in DHFR activity reduces BH4 content to enhance lipid peroxidation and sensitizes cells to ferroptosis (Lu et al., 2024), but the detail process is still unknown (Figure 1)
Pollak, N