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Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

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Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66

In addition to energy repletion, Phase II reactions require an abundance of co-factors