Hepatology 78 , 18281842 (2023)
Tirzepatide (Zepbound and Mounjaro): weekly vials you load into a syringe yourself or preloaded injection pens Semaglutide (Wegovy and Ozempic): weekly, preloaded injection pen in various doses Liraglutide (Saxenda and Victoza): daily injectable pens Other GLP-1s and weight-loss meds: Trulicity , a less common GLP-1 (dulaglutide), comes in the form of a pen for once-weekly injections Bydureon BCise (once-weekly preloaded injection) Rybelsus (oral method) Contrave and Xenical (weight-loss drugs that are not GLP-1s and typically come at a much cheaper price tag) Other medications: antibiotics, antidepressants, asthma medication, and much, much more Note: Ozempic, Mounjaro, Victoza, Trulicity, Bydureon, and Rybelsus are FDA approved for type 2 diabetes only and must be prescribed off-label for use as a weight-loss treatment
The strongest single piece of human evidence is Watson et al
Understanding this medication's glucose-dependent mechanism is essential for safe prescribing
These results show that, compared to the Sham + DMSO group, the CCI group exhibited a significant increase in mechanical withdrawal frequency and a decrease in thermal withdrawal latency on day 7 post-CCI, which indicates the emergence of mechanical and thermal pain hypersensitivity
Choose Low-Sugar, High-Protein Snacks Rather than completely cutting out sweet things, go for low sugar snacks for weight loss meds that satisfy without triggering a binge
